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Evidence-Based Medicine Library Guide: Trials

Finding the Evidence in the Practice of Evidence-Based Healthcare

Cochrane Library

Cochrane Library consists of the following:

Cochrane Database of Systematic Reviews - full text available.

Cochrance Central Register of Controlled Trials (CENTRAL)

Cochrane Methodology Register.  A bibliography of publications that report on methods used in the conduct of controlled trials. They do not contain the full text of the article.

Database of Abstracts of Reviews of Effects (DARE). It contains abstracts of systematic reviews not yet carried out by the Cochrane Collaboration. Each abstract includes a summary of the review together with a critical commentary about the overall quality.

Health Technology Assessment Database. Brings together studies of the medical, social, ethical, and economic implications of healthcare interventions from around the world.

NHS Economic Evaluation Database. Systematically identifies economic evaluations from around the world, appraising their quality, and highlighting their relative strengths and weaknesses.

PubMed

There are a number of ways of retrieving trials from PubMed:

  • Basic search - filter to clinical trial, add additional filters to publication type options such as, controlled clinical trial or randomized controlled trial
  • PubMed Clinical Queries - perform your search and choose Clinical Studies. You can filter further to etiology ,diagnosis,  therapy(default), prognosis or clinical prediction guides
  • MeSH search - search on Clinical trial[Publication type] which includes types of trials such as RCT, Controlled Clinical Trial, Clinical Trial Phase I etc. Also search on MeSH heading Clinical Trials as Topic.
  • Advanced Search - construct your own search string in the Advanced Search Builder making use of the index lists pertaining to a particular field such as publication type

Other sources of trials

In addition to the Cochrane Library and Medline, there are many other important sources of trials, particularly randomized controlled trials as listed below: