NISH (NITAG Support Hub) 7: Mpox vaccines: Systematic Reviews on Mpox

Brochero, C. D., Nocua-Báez, L. C., Cortes, J. A., Charniga, K., Buitrago-Lopez, A., & Cucunubá, Z. M. (2025). Decoding mpox: a systematic review and meta-analysis of the transmission and severity parameters of the 2022–2023 global outbreak. BMJ Global Health, 10(1). https://gh.bmj.com/content/bmjgh/

Cadmus, S., Akinseye, V., Besong, M., Olanipekun, T., Fadele, J., Cadmus, E., Ansumana, R., Oluwayelu, D., Odemuyiwa, S. O., & Tomori, O. (2024). Dynamics of Mpox infection in Nigeria: a systematic review and meta-analysis. Scientific Reports, 14(1), 7368. https://www.nature.com/articles/s41598-024-58147-y.pdf

Cheuyem, F. Z. L., Takpando-le-grand, D. R., Achangwa, C., Boukeng, L. B. K., Dabou, S., Mutarambirwa, H. D., Otsali, R. K. N., Nouko, A., Edzamba, M. F., & Tsafack, M. G. M. (2025). Mpox clinical and epidemiological patterns in the Central African Republic: a systematic review and meta-analysis. medRxiv, 2025.2007. 2009.25331215. https://www.medrxiv.org/content/

Cheuyem, F. Z. L., Zemsi, A., Ndungo, J. H., Achangwa, C., Takpando-le-grand, D. R., Goupeyou-Youmsi, J., Dabou, S., Adama, M., Nouko, A., & Mbang, M. A. (2025). Mpox severity and mortality in the most endemic focus in africa: a systematic review and meta-analysis (1970-2024). medRxiv, 2025.2004. 2007.25325410.

Jadhav, V., Paul, A., Trivedi, V., Bhatnagar, R., Bhalsinge, R., & Jadhav, S. V. (2025). Global epidemiology, viral evolution, and public health responses: a systematic review on Mpox (1958–2024). Journal of Global Health, 15, 04061. https://pmc.ncbi.nlm.nih.gov/articles/PMC11893143/

Ndembi, N., Folayan, M. O., Komakech, A., Mercy, K., Tessema, S., Mbala-Kingebeni, P., Ngandu, C., Ngongo, N., Kaseya, J., & Abdool Karim, S. S. (2025). Evolving epidemiology of mpox in Africa in 2024. New England Journal of Medicine, 392(7), 666-676. https://www.nejm.org/doi/pdf/10.1056

Okoli, G. N., Van Caeseele, P., Askin, N., & Abou-Setta, A. M. (2024). A global systematic evidence review with meta-analysis of the epidemiological characteristics of the 2022 Mpox outbreaks. Infection, 52(3), 901-921. (NOT OA)

Ugwu, C. L. J., Bragazzi, N. L., Wu, J., Kong, J. D., Asgary, A., Orbinski, J., & Woldegerima, W. A. (2024). Risk Factors of Human Mpox (Monkeypox) Infection: A Systematic Review and Meta-Analysis. medRxiv, 2024.2008. 2014.24311975. https://www.medrxiv.org/content/1

Ugwu, C. L. J., Bragazzi, N. L., Wu, J., Kong, J. D., Asgary, A., Orbinski, J., & Woldegerima, W. A. (2025). Risk factors associated with human Mpox infection: a systematic review and meta-analysis. BMJ Global Health, 10(2).https://gh.bmj.com/content/10/2/e016937

Anjorin, A., Odetokun, I. A., Ashaka, O. S., Fadipe, T. O., Muhammad, A., Nyandwi, J., Morakinyo, O., Dauda, A., Adetona, M., & Tijani, S. (2024). Critical appraisal of Monkeypox (Mpox) in Africa using scoping and systematic review methods. https://ir.unilag.edu.ng/handle/123456789/13043

Beiras, C. G., Malembi, E., Escrig-Sarreta, R., Ahuka, S., Mbala, P., Mavoko, H. M., Subissi, L., Abecasis, A. B., Marks, M., & Mitjà, O. (2025). Concurrent outbreaks of mpox in Africa—an update. The lancet, 405(10472), 86-96. https://www.thelancet.com/journals/lancet

Clemente, N. S., Coles, C., Paixao, E. S., Brickley, E. B., Whittaker, E., Alfven, T., Rulisa, S., Higuita, N. A., Torpiano, P., & Agravat, P. (2024). Paediatric, maternal, and congenital mpox: a systematic review and meta-analysis. The Lancet Global Health, 12(4), e572-e588. https://www.thelancet.com/action/showPdf?pii=S2214-109X%2823%2900607-1

Shabil, M., Gaidhane, S., Roopashree, R., Kaur, M., Srivastava, M., Barwal, A., Siva Prasad, G., Rajput, P., Syed, R., & Dev, A. (2025). Association of HIV infection and hospitalization among mpox cases: a systematic review and meta-analysis. BMC infectious diseases, 25(1), 102. https://bmcinfectdis.biomedcentral.com/counter/

Eslami A, Alimoghadam S, Khoshravesh S, Shirani M, Alimoghadam R, Alavi Darazam I. (2024) Mpox vaccination and treatment: a systematic review. J Chemother, 85-109. doi: 10.1080/1120009X.2023.2289270.

Berry MT, Khan SR, Schlub TE, Notaras A, Kunasekaran M, Grulich AE, MacIntyre, CR, Davenport MP, Khoury DS. (2024) Predicting vaccine effectiveness for mpox. Nat Commun. p3856. doi: 10.1038/s41467-024-48180-w.

Liu H, Wang W, Zhang Y, Wang F, Duan J, Huang T, Huang X, Zhang T. (2024). Global perspectives on smallpox vaccine against monkeypox: a comprehensive meta-analysis and systematic review of effectiveness, protection, safety and cross-immunogenicity. Emerg Microbes Infect. p2387442. doi:10.1080/22221751.2024.2387442.

Pischel L, Martini BA, Yu N, Cacesse D, Tracy M, Kharbanda K, Ahmed N, Patel KM, Grimshaw AA, Malik AA, Goshua G, Omer SB. (2024). Vaccine effectiveness of 3rd generation mpox vaccines against mpox and disease severity: A systematic review and meta-analysis. Vaccine. p 126053. doi: 10.1016/j.vaccine.2024.06.021

Mason LMK, Betancur E, Riera-Montes M, Lienert F, Scheele S. (2024) MVA-BN vaccine effectiveness: A systematic review of real-world evidence in outbreak settings. Vaccine. p 126409. doi: 10.1016/j.vaccine.2024

Malone SM, Mitra AK, Onumah NA, Brown A, Jones LM, Tresvant D, Brown CS, Onyia AU, Iseguede FO. (2023) Safety and Efficacy of Post-Eradication Smallpox Vaccine as an Mpox Vaccine: A Systematic Review with Meta-Analysis. Int J Environ Res Public Health. p 2963. doi: 10.3390/ijerph20042963.

Taha AM, Mahmoud AM, Abouelmagd K, Saed SAA, Khalefa BB, Shah S, Satapathy P, Shamim MA, Sah S, Serhan HA, Donovan S, Sah R, Barboza JJ. (2024). Effectiveness of a single dose of JYNNEOS vaccine in real world: A systematic review and meta-analysis. Health Sci Rep. e70069. doi: 10.1002/hsr2.70069.

Sudarmaji N, Kifli N, Hermansyah A, Yeoh SF, Goh BH, Ming LC (2022). Prevention and Treatment of Monkeypox: A Systematic Review of Preclinical Studies. Viruses. p 2496. doi: 10.3390/v14112496

Abejegah, C., Obohwemu, K. O., & Mdegela, M. (2024). Clinical manifestations and outcomes of human Mpox infection from 1970 to 2023: A Systematic Literature Review. Clinical Infection in Practice, 24, 100397. https://doi.org/10.1016/j.clinpr.2024.100397

Lekeumo Cheuyem, F. Z., Amani, A., Umar, A. A., Achangwa, C., Ajong, B. N., Dabou, S., Goupeyou-Youmsi, J., Pilo Ndibo, G. R., Tchamani, R., & Eno, E. (2025). Mpox vaccine uptake in the most endemic focus in Africa: a systematic review and meta-analysis (1970–2024). medRxiv, 2025.2005. 2023.25327865.https://www.medrxiv.org/content/

Musuka, G., Moyo, E., Tungwarara, N., Mhango, M., Pierre, G., Saramba, E., Iradukunda, P. G., & Dzinamarira, T. (2024). A critical review of mpox outbreaks, risk factors, and prevention efforts in Africa: lessons learned and evolving practices. IJID Regions, 12, 100402. https://pmc.ncbi.nlm.nih.gov/articles/PMC11326932/

León-Figueroa, D. A., Barboza, J. J., Siddiq, A., Sah, R., Valladares-Garrido, M. J., & Rodriguez-Morales, A. J. (2024). Knowledge and attitude towards mpox: Systematic review and meta-analysis. PLoS One, 19(8), e0308478. https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0308478&type=printable

Liu J, Liu S, Yu S, Du X, Hao J, Hui R, Buh A, Chen W, Chen J. (2024). Willingness to receive mpox vaccine among men who have sex with men: a systematic review and meta-analysis. BMC Public Health. p 1878. doi:10.1186/s12889-024-19260-9

Alorfi NM, Alshehri FS, Haseeb A. (2023). Characterization of interventional clinical trials for monkeypox; systematic review of ClinicalTrials.gov database. Front Public Health. 1144325. doi:10.3389/fpubh.2023.1144325.

Nave L, Margalit I, Tau N, Cohen I, Yelin D, Lienert F, Yahav D. (2023). Immunogenicity and Safety of Modified Vaccinia Ankara (MVA) Vaccine-A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Vaccines (Basel). p 1410. doi: 10.3390/vaccines11091410