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NISH (NITAG Support Hub) 10: Hepatitis B Birth Dose Vaccines: Domain 1 : Disease Burden

This Library Guide is a collection of useful documents & evidence on the safety, efficacy, effectiveness and impact of the Hepatitis B Birth Dose vaccine to support NITAG members and other policy makers throughout Africa with making evidence-based recomm

Keywords used

 

"Hepatitis B Birth Dose" AND “disease burden” OR epidemiology OR incidence OR cases OR hospitalization OR case fatality OR  “clinical characteristics” OR “cost of health care” OR “alternative prevention”

"Hepatitis B Birth Dose" AND “disease burden” - Africa

 

Izudi, J., Kiroro, F., Runyenje, C., Otieno, P., Kavao Mutua, M., Mbuthia, M., Pierre Donfouet, H. P., Treleaven, E., & Asiki, G. (2025). Text message reminders to improve the timeliness of birth dose vaccine administration among newborns in an urban informal settlement in Kenya. International Journal of Epidemiology, 54(2), dyaf024. https://doi.org/10.1093/ije/dyaf024

Al-Busafi, S. A., & Alwassief, A. (2024). Global perspectives on the hepatitis B vaccination: challenges, achievements, and the road to elimination by 2030. Vaccines, 12(3), 288. https://doi.org/10.3390/vaccines12030288

Alemayehu, Tinsae, Ross N. England, Benson Oguttu, and Daniel Jarovsky. ‘Should Birth-Dose Vaccines for Preterm Newborns Still Be Debated?’ International Journal of Infectious Diseases 154 (2025). https://www.ijidonline.com/action/showPdf?pii=S1201-9712%2825%2900089-X

Arefaine, Mebrihit, Asgeir Johannessen, Tilahun Teklehaymanot, Adane Mihret, Dawit Hailu Alemayehu, Mahlet Osman, Andargachew Mulu, and Nega Berhe. ‘A Prospective, Multicenter Study of Hepatitis B Birth-Dose Vaccine with or without Hepatitis B Immunoglobulin in Preventing Mother-to-Child Transmission of Hepatitis B Virus in Ethiopia’. Vaccine 42, no. 26 (2024): 126461. https://doi.org/10.1016/j.vaccine.2024.126461

Bassoum, Oumar, Mouhamadou Faly Ba, Ndeye Mareme Sougou, Adama Sow, and Ibrahima Seck. ‘Determinants of Timely Administration of the Birth Dose of Hepatitis B Vaccine in Senegal in 2019: Secondary Analysis of the Demographic and Health Survey’. PLOS Global Public Health 4, no. 8 (2024): e0002734. https://doi.org/10.1371/journal.pgph.0002734

Faniyi, Ayodeji Amos, Olalekan John Okesanya, Emery Manirambona, Tolutope Adebimpe Oso, Noah Olabode Olaleke, Ruth Nimota Nukpezah, Ayodele O. Ilesanmi, and Don Eliseo Lucero-Prisno III. ‘Advancing Public Health Policies to Combat Hepatitis B in Africa: Challenges, Advances, and Recommendations for Meeting 2030 Targets’. Journal of Medicine, Surgery, and Public Health 2 (2024): 100058. https://doi.org/10.1016/j.glmedi.2024.100058

Kanu, Florence A., Catherine Freeland, Ugochukwu Uzoechina Nwokoro, Yahaya Mohammed, Hadley Ikwe, Belinda Uba, Hardeep Sandhu, Qian An, Adeyelu Asekun, and Charles Akataobi. ‘Evaluation of Interventions to Improve Timely Hepatitis B Birth Dose Vaccination among Infants and Maternal Tetanus Vaccination among Pregnant Women in Nigeria’. Vaccine 42, no. 24 (2024): 126222. https://doi.org/10.1016/j.vaccine.2024.126222

Moonsamy, Shelina, Pavitra Pillay, Beverley A. Singh, Adrian Puren, John W. Ward, and Nishi Prabdial-Sing. ‘Hepatitis B Infection (HBsAg and HBeAg) Status among Women Attending Antenatal Care at Public Healthcare Facilities of South Africa, 2017’. PLOS Global Public Health 5, no. 1 (2025): e0003567. https://doi.org/10.1371

Ndow, Gibril, Rohey Bangura, Erwan Vo-Quang, Fatoumata Touray, Abdoulie Jatta, Jainaba Barry, Isatou Mahmoud, Sulayman Bah, Fatou Bintou Nyassi, and Amie Ceesay. ‘Residual Risk of Hepatitis B Virus (HBV) Mother-to-Child Transmission and Gaps in HBV Care Cascades among Pregnant Women in The Gambia: The INFANT-B Study’. The Journal of Infectious Diseases, 2025, jiaf214. https://doi.org/10.1093/infdis/jiaf214

Olakunde, Babayemi O., Ijeoma M. Ifeorah, Daniel A. Adeyinka, Olubunmi A. Olakunde, Temitayo Ogundipe, John O. Olawepo, and Echezona E. Ezeanolue. ‘Immune Response to Hepatitis B Vaccine among Children under 5 Years in Africa: A Meta-Analysis’. Tropical Medicine and Health 52, no. 1 (2024): 28. Olakunde et al. Olakunde et al. https://doi.org/10.1186/s41182-024-00594-4

Olakunde, Babayemi Oluwaseun, Ijeoma Uchenna Itanyi, Tonia Chinyelu Onyeka, Elijah Paintsil, Kwasi Torpey, Nwamaka Lasebikan, Chibuike Ogwuegbu Chigbu, and Echezona Edozie Ezeanolue. ‘Hepatitis B Vaccine Birth Dose Coverage among Hepatitis B-Exposed and Hepatitis B-Unexposed Infants: Evidence from the Healthy Beginning Initiative Program in Benue State, Nigeria’. The Pan African Medical Journal 47 (2024): 67. https://www.panafrican-med-journal.com//content/article/47/67/full 

Riches, Nicholas, Marc YR Henrion, Peter MacPherson, Camilla Hahn, Rabson Kachala, Thomas Mitchell, Daniel Murray, Wongani Mzumara, Owen Nkoka, and Alison J. Price. ‘Vertical Transmission of Hepatitis B Virus in the WHO African Region: A Systematic Review and Meta-Analysis’. The Lancet Global Health 13, no. 3 (2025): e447–58. https://www.thelancet.com/action/showPdf?pii=S2214-109X%2824%2900506-0

Solomon-Rakiep, Tasneem, Jill Olivier, and Edina Amponsah-Dacosta. ‘Towards Contextualized Complex Systems Approaches to Scaling-up Hepatitis B Birth-Dose Vaccination in the African Region: A Qualitative Systematic Review’. Frontiers in Public Health 12 (2024): 1389633. https://doi.org/10.3389/fpubh.2024.1389633

Shimakawa, Y. et al. 2022. Residual risk of mother-to-child transmission of hepatitis B virus infection despite timely birth-dose vaccination in Cameroon (ANRS 12303): a single-centre, longitudinal observational study. Lancet Glob Health

Spearman, C. W. ‘Demystifying the Management of Hepatitis B–the WHO 2024 Guidelines on the Management of Hepatitis B’. South African Journal of Gastroenterology and Hepatology 1, no. 1 (2024): 19–21. https://doi.org/10.36303/SAJGH.0497

Tohme, Rania A., Su Wang, Benjamin Cowie, Sandra Dudareva, and Carolyn Wester. ‘Eliminating Perinatal Transmission of Hepatitis B Virus: It Is Time for Action’. Journal of the International AIDS Society 27, no. 7 (2024): e26337. doi: 10.1002/jia2.26337

Torimiro, Judith N., and Evelyn M. Mah. ‘Unmet Needs for the Prevention of Vertical Transmission of Hepatitis B in Africa’. The Lancet Global Health 13, no. 3 (2025): e377–78. https://www.thelancet.com/action/showPdf?pii=S2214-109X%2824%2900565-5

Torimiro, Judith Ndongo Embola, Kerina Duri, Nadège M. Goumkwa, Solange M. Atah, Juliette-Laure Ndzie Ondigui, Cindy Lobe, Marielle Bouyou, Bénédicte Ndeboko, Ali Mahamat Moussa, and Camengo Police. ‘Toward the Elimination of Hepatitis B: Networking to Promote the Prevention of Vertical Transmission of Hepatitis B Virus through Population-Based Interventions and Multidisciplinary Groups in Africa’. Frontiers in Public Health 12 (2024): 1283350. https://doi.org/10.3389/fpubh.2024.1283350 

Tulenko, Samantha E., Patrick Ngimbi, Kashamuka Mwandagalirwa, Martine Tabala, Jolie Matondo, Sarah Ntambua, Nana Mbonze, Charles Mbendi, Christophe Luhata, and Ravi Jhaveri. ‘Immunogenicity of a Birth Dose of Hepatitis B Vaccine in Kinshasa, Democratic Republic of Congo: A Randomised, Controlled Trial’. Journal of Viral Hepatitis 31, no. 12 (2024): 795–807. https://doi.org/10.1111/jvh.14003

Uba, Belinda V., Yahaya Mohammed, Ugochukwu Uzoechina Nwokoro, Rhoda Fadahunsi, Adefisoye Adewole, Gideon Ugbenyo, Edwin Simple, Margeret Osas Wisdom, Ndadilnasiya E. Waziri, and Charles A. Michael. ‘Health Facility Capacity and Health-Care Worker Knowledge, Attitudes, and Practices of Hepatitis B Vaccine Birth-Dose and Maternal Tetanus-Diphtheria Vaccine Administration in Nigeria: A Baseline Assessment’. Annals of African Medicine 24, no. 1 (2025): 113–23. (NOT OA).

Voeller, Alexis S., Asgeir Johannessen, Zebideru Zewdie Abebe, Wegene Adugna, Ivane Gamkrelidze, Eleni Seyoum, Lia Tadesse Gebremedhin, Mirtie Getachew Meselu, Seblewongel Abate Nigussie, and Asmamaw Silesh. ‘The Disease and Economic Burden of HBV and HCV in Ethiopia’. Journal of Viral Hepatitis 32, no. 2 (2025): e14053.  https://doi.org/10.1111/jvh.14053

Wondmeneh, Temesgen Gebeyehu, and Ayal Tsegaye Mekonnen. ‘Epidemiology of Hepatitis B Virus Infection among Pregnant Women in Africa: A Systematic Review and Meta-Analysis’. BMC Infectious Diseases 24, no. 1 (2024): 921. https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09839-3

 

"Hepatitis B Birth Dose" AND “disease burden” - general

Cui, Fuqiang, Diana Faini, Devin Razavi-Shearer, Homie Razavi, Casimir Manzengo Mingiedi, Monica Alonso Gonzalez, Ahmed Sabry Alaama, Antons Mozalevskis, Polin Chan, and Kiyohiko Izumi. ‘Global Hepatitis Burden–Data for Action on Access of a Leading Infectious Disease Burden’, n.d. http://dx.doi.org/10.2139/ssrn.5196987

Easterbrook, Philippa J., Niklas Luhmann, Sahar Bajis, Myat Sandi Min, Morkor Newman, Olufunmilayo Lesi, and Meg C. Doherty. ‘WHO 2024 Hepatitis B Guidelines: An Opportunity to Transform Care’. The Lancet Gastroenterology & Hepatology 9, no. 6 (2024): 493–95. https://www.thelancet.com/action/showPdf?pii=S2468-1253%2824%2900089-X

Gorar, Zulfikar Ali, and Zahid Ahmad Butt. ‘Impact of Hepatitis B Birth Dose on Immune Response in Pakistani Children: An Open-Label, Non-Inferiority Randomized Controlled Trial, Implications for Achieving SDG Target’. Infectious Diseases 56, no. 1 (2024): 1–10. https://doi.org/10.1080/23744235.2023.2258208

He, Quanwei, Xiujuan Chang, Ran Xu, Wei Han, Sihao Wang, Shujuan Gong, Jiagan Huang, Jiangtao Liu, Rugang Zhang, and Yongping Yang. ‘Global Temporal Trends and Projections of Hepatitis B-Related Cirrhosis among Adolescents and Young Adults from 1990 to 2035: An Analysis Based on the Global Burden of Disease Study 2021’. Frontiers in Public Health 12 (2025): 1494388. https://doi.org/10.3389/fpubh.2024.1494388

Hutton, David W., Mehlika Toy, Danwei Yang, Hanwen Zhang, Senad Handanagic, Paige A. Armstrong, Annemarie Wasley, Nicolas A. Menzies, Hang Pham, and Joshua A. Salomon. ‘Modelling the Potential Impact of Global Hepatitis B Vaccination on the Burden of Chronic Hepatitis B in the United States’. Journal of Viral Hepatitis 31, no. 10 (2024): 614–22. https://doi.org/10.1111/jvh.13982

Li, Jinbo, Ziyi Gao, Hongjing Bai, Weigang Wang, Yandi Li, Jia Lian, Yaling Li, Yongliang Feng, and Suping Wang. ‘Global, Regional, and National Total Burden Related to Hepatitis B in Children and Adolescents from 1990 to 2021’. BMC Public Health 24, no. 1 (2024): 2936. Li et al. https://doi.org/10.1186/s12889-024-20462-4

O’Mahony, Elizabeth, Sophie Raghunanan, Ashley Brown, and Caroline Foster. ‘Prevention of Vertical Transmission of Hepatitis B: A Retrospective Review of a 5‐year Maternal–Infant Cohort in London’. Journal of Paediatrics and Child Health 60, no. 9 (2024): 422–27.  https://doi.org/10.1111/jpc.16609

Stockdale, Alexander, and Danjuma Adda. ‘Preventing Vertical Transmission of HBV in LMICs: What Could HBcrAg Rapid Tests Add?’ The Lancet Gastroenterology & Hepatology 10, no. 5 (2025): 405–6. https://doi.org/10.1016/S2468-1253(25)00057-3

Vo‐Quang, Erwan, and Maud Lemoine. ‘Global Elimination of HBV: Is It Really Achievable?’ Journal of Viral Hepatitis 31 (2024): 4–12. https://doi.org/10.1111/jvh.13955

Yang, Shaojie, Lin Zhong, Lu Huang, Shengyuan Lin, and Yubin Li. ‘Global Burden and Trends of Viral Hepatitis among Women of Childbearing Age from 1990 to 2021’. Frontiers in Microbiology 16 (2025): 1553129. https://doi.org/10.3389/fmicb.2025.1553129