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NISH (NITAG Support Hub) 11: Measles Containing Vaccine (MCV) Vial Presentation Switch LibGuide: Scientific articles

This Library Guide is a collection of useful documents & evidence on the efficacy, effectiveness and impact of the Measles Containing Vaccine (MCV) switch to support NITAGs

PICO used for search terms

P                   child OR children OR baby OR infant OR babies OR newborn OR neonate

I                     5-dose MCV OR five-dose OR 5-dose MR OR 5-dose measles vaccine OR 5-dose MMR

C                   10-dose MCV OR 10-dose MR OR 10-dose measles vaccine OR 10-dose MMR

O                   safety OR effectiveness OR efficacy OR coverage OR barriers OR facilitators OR missed   opportunities OR vaccine wastage OR advantages OR challenges OR effects OR impacts OR   results

Publications from and in Africa

NEW!!

Lau, D. K., Seebacher, S., Abdi, A., Ahmed, S., Nur, M. B., Ciglenecki, I., ... & Gignoux, E. (2025). The challenge of protracted measles outbreaks in Kismayo, Somalia: A mixed-method investigation of measles burden and vaccination coverage during a 2020–2021 outbreak. PLOS Global Public Health, 5(8), e0005143. https://doi.org/10.1371/journal.pgph.0005143

Adisu MA, Habtie TE, Kitaw TA, Zemariam AB
Uptake of the Second Dose of the Measles Vaccine and Its Determinants Among Children Aged Less Than 5 Years: Systematic Review and Meta-Analysis. JMIR Public Health Surveill 2025;11:e77195
doi: 10.2196/77195 PMID: 40864500

Ninsiima M, Muhoozi M, Luzze H, Kasasa S (2025) Vaccine wastage rates and attributed factors in rural and urban areas in Uganda: Case of Mukono and Kalungu districts. PLOS Glob Public Health 5(6): e0003745.  https://doi.org/10.1371/journal.pgph.0003745

Mbabazi, W. and Davis, R. (2025). New approaches to measles eradication, with special reference to Africa. Pan African Medical Journal. 2025;51(1):4. doi: 10.11604/pamj.supp.2025.51.1.47547 OR  https://www.panafrican-med-journal.com//content/series/51/1/4/full

Addis, M., Mekonnen, W., & Estifanos, A. S. (2024). Health system barriers to the first dose of measles immunization in Ethiopia: a qualitative study. BMC Public Health, 24(1), 665. https://doi.org/10.1186/s12889-024-18132-6

Assi, T. M., Brown, S. T., Djibo, A., Norman, B. A., Rajgopal, J., Welling, J. S., ... & Lee, B. Y. (2011). Impact of changing the measles vaccine vial size on Niger's vaccine supply chain: a computational model. BMC public health, 11, 1-9. http://www.biomedcentral.com/1471-2458/11/425

Byberg, S., Fisker, A. B., Rodrigues, A., Balde, I., Enemark, U., Aaby, P., ... & Griffiths, U. K. (2017). Household experience and costs of seeking measles vaccination in rural Guinea‐Bissau. Tropical medicine & international health, 22(1), 12-20. https://doi.org/10.1111/tmi.12793

Byberg, S., Fisker, A. B., Thysen, S. M., Rodrigues, A., Enemark, U., Aaby, P., ... & Griffiths, U. K. (2017). Cost-effectiveness of providing measles vaccination to all children in Guinea-Bissau. Global health action, 10(1), 1329968.  https://doi.org/10.1080/16549716.2017.1329968

Jansen, M., Spasenoska, D., Nadjib, M., Ararso, D., Hutubessy, R., Kahn, A. L., & Lambach, P. (2024). National immunization program decision making using the CAPACITI decision-support tool: user feedback from Indonesia and Ethiopia. Vaccines, 12(3), 337.  https://doi.org/10.3390/vaccines12030337

Kanagat, N., Krudwig, K., Wilkins, K. A., Kaweme, S., Phiri, G., Mwansa, F. D., ... & Tran, T. C. (2020). Health care worker preferences and perspectives on doses per container for 2 lyophilized vaccines in Senegal, Vietnam, and Zambia. Global Health: Science and Practice, 8(4), 680-688. //https:www..ghspjournal.org/content/ghsp/8/4/680.full.pdf

Ko, M., Frivold, C., Mvundura, M., Soble, A., Gregory, C., Christiansen, H., ... & Amorij, J. P. (2024). An Application of an Initial Full Value of Vaccine Assessment Methodology to Measles-Rubella MAPs for Use in Low-and Middle-Income Countries. Vaccines, 12(9), 1075.  https://doi.org/10.3390/vaccines12091075

Krudwig, K., Knittel, B., Karim, A., Kanagat, N., Prosser, W., Phiri, G., ... & Steinglass, R. (2020). The effects of switching from 10 to 5-dose vials of MR vaccine on vaccination coverage and wastage: A mixed-method study in Zambia. Vaccine, 38(37), 5905-5913. https://doi.org/10.1016/j.vaccine.2020.07.012

Lambo, K., Prescott, M., Wiwa, O., Asolo, J. A., & Daradara, K. (2024). Minimizing Vaccine Wastage in Nigeria: A National Assessment of Vaccine Wastage Rates and Potential Determinants. Vaccines, 12(8), 900.                                                                https://doi.org/10.3390/vaccines12080900

Majekodunmi, O. B., Oladele, E. A., & Greenwood, B. (2022). Factors affecting poor measles vaccination coverage in sub-Saharan Africa with a special focus on Nigeria: a narrative review. Transactions of The Royal Society of Tropical Medicine and Hygiene, 116(8), 686-693.  https://doi.org/10.1093/trstmh/trac013

Masresha, B. G., Luce, R., Okeibunor, J., Shibeshi, M. E., Kamadjeu, R., & Fall, A. (2018). Introduction of the second dose of measles containing vaccine in the childhood vaccination programs within the WHO Africa Region–lessons learnt. Journal of immunological sciences, 113.   https://pmc.ncbi.nlm.nih.gov/articles/PMC6372060/pdf/emss-81553.pdf

Masresha, B. G., Shibeshi, M. E., Grant, G. B., Hatcher, C., & Wiysonge, C. S. (2024). Progress with the Second Dose Measles Vaccine Introduction and Coverage in the WHO African Region. Vaccines, 12(9), 1069.    doi: 10.3390/vaccines12091069

Masresha, B. G., Wiysonge, C. S., Katsande, R., O’Connor, P. M., Lebo, E., & Perry, R. T. (2024). Tracking Measles and Rubella Elimination Progress—World Health Organization African Region, 2022–2023. Vaccines, 12(8), 949. https://doi.org/10.3390/vaccines12080949

Masresha, B. G., Wiysonge, C. S., Katsande, R., O’Connor, P. M., Lebo, E., & Perry, R. T. (2024). Tracking Measles and Rubella Elimination Progress—World Health Organization African Region, 2022–2023. Vaccines, 12(8), 949. https://doi.org/10.3390/vaccines12080949

Mvundura, M., Ng, J., Reynolds, K., Ng, Y. T., Bawa, J., Bambo, M., ... & Robertson, J. (2023). Vaccine wastage in Ghana, Mozambique, and Pakistan: An assessment of wastage rates for four vaccines and the context, causes, drivers, and knowledge, attitudes and practices for vaccine wastage. Vaccine, 41(28), 4158-4169. https://doi.org/10.1016/j.vaccine.2023.05.033

Saidu, Y., Gu, J., Ngenge, B. M., Nchinjoh, S. C., Adidja, A., Nnang, N. E., ... & Clemens, R. (2023). The faces behind vaccination: unpacking the attitudes, knowledge, and practices of staff of Cameroon’s Expanded program on Immunization. Human Resources for Health, 21(1), 88.     https://doi.org/10.1186/s12960-023-00869-7

Simuyemba, M. C., Chama-Chiliba, C., Chompola, A., Sinyangwe, A., Bchir, A., Asiimwe, G., & Masiye, F. (2022). Evaluating the functionality and effectiveness of ZITAG and related expanded programme on immunisation technical committees in Zambia. Vaccine: X, 12, 100193.  https://doi.org/10.1016/j.jvacx.2022.100193

Solomon, K., Aksnes, B. N., Woyessa, A. B., Sadi, C. G., Matanock, A. M., Shah, M. P., ... & Kaba, M. (2024). Qualitative Insights on Barriers to Receiving a Second Dose of Measles-Containing Vaccine (MCV2), Oromia Region of Ethiopia. Vaccines, 12(7), 702. https://doi.org/10.3390/vaccines12070702

 

Publications in general

Crowcroft, N. S., Minta, A. A., Bolotin, S., Cernuschi, T., Ariyarajah, A., Antoni, S., ... & O’Connor, P. M. (2024). The problem with delaying measles elimination. Vaccines, 12(7), 13. //doi.org/10.3390/vaccines12070813

Azam, J. M., Saitta, B., Bonner, K., Ferrari, M. J., & Pulliam, J. R. (2021). Modelling the relative benefits of using the measles vaccine outside cold chain for outbreak response. Vaccine, 39(40), 5845-5853   https://doi.org/10.1016/j.vaccine.2021.08.053

Gavi, The Vaccine Alliance. New 2021–2025 high level strategy to leave no-one behind with immunisation approved by GaviBoard. 2022. https://www.gavi.org/news/media-room/new-2021-2025-high-level-strategy-leave-no-one-behind-immunisation-approved-gavi.

Hagedorn, B. L., Dabbagh, A., & McCarthy, K. A. (2019). The cost saving opportunity of introducing a card review into measles-containing vaccination campaigns. Vaccine, 37(41), 6093-610  https://doi.org/10.1016/j.vaccine.2019.08.049

Halsey, N. A., Berry, S., Carrasco, P., De Quadros, C., Martinez, J., Arroyo, J. J., ... & Sienko, D. (1989). Field evaluation of a simplified unit-dose syringe for administration of measles vaccine. Clinical Infectious Diseases, 11(Supplement_3), S631-S638. https://doi.org/10.1093/clinids/11.Supplement_3.S631

Lee, B. Y., Assi, T. M., Rookkapan, K., Connor, D. L., Rajgopal, J., Sornsrivichai, V., ... & Burke, D. S. (2011). Replacing the measles ten-dose vaccine presentation with the single-dose presentation in Thailand. Vaccine, 29(21), 3811-3817.                     https://doi.org/10.1016/j.vaccine.2011.03.013

Lee, B. Y., Norman, B. A., Assi, T. M., Chen, S. I., Bailey, R. R., Rajgopal, J., Brown, S. T., Wiringa, A. E., & Burke, D. S. (2010). Single versus multi-dose vaccine vials: an economic computational model. Vaccine, 28(32), 5292–5300. https://doi.org/10.1016/j.vaccine.2010.05.048

Oberoi, S., Mishra, P., Patnaik, S., & Garg, A. (2021). Vaccine wastage at primary, secondary, and tertiary level of healthcare system—a study from Northern India. Journal of Family Medicine and Primary Care, 10(2), 877-882.              https://journals.lww.com/jfmpc/fulltext/2021/10020/Vaccine

Packham, A., Taylor, A. E., Karangwa, M. P., Sherry, E., Muvunyi, C., & Green, C. A. (2024). Measles vaccine coverage and disease outbreaks: A systematic review of the early impact of COVID-19 in low and lower-middle income countries. International Journal of Public Health, 69, 1606997.   https://doi.org/10.3389/ijph.2024.1606997

UNICEF. MR Vaccine, Vial of 10 doses. https://supply.unicef.org/s359348.html

UNICEF. 2022. Measles and Measles-Rubella Combination Vaccines: Supply and Demand    Update. https://www.unicef.org/supply/media/14281/file/Measles-Measles-Rubella-Combination-Vaccines-Market-Supply-Note-Oct-2022.pdf

Wallace, A. S., Krey, K., Hustedt, J., Burnett, E., Choun, N., Daniels, D., ... & Duncan, R. (2018). Assessment of vaccine wastage rates, missed opportunities, and related knowledge, attitudes and practices during introduction of a second dose of measles-containing vaccine into Cambodia’s national immunization program. Vaccine, 36(30), 4517-4524. https://www.linksbridge.com/case-study-mcv-5-dose

Wedlock, P. T., Mitgang, E. A., Oron, A. P., Hagedorn, B. L., Leonard, J., Brown, S. T., ... & Lee, B. Y. (2019). Modeling the economic impact of different vial-opening thresholds for measles-containing vaccines. Vaccine, 37(17), 2356-2368. https://doi.org/10.1016/j.vaccine.2019.03.017

Wedlock, P. T. (2019). Assessing vial-opening thresholds for measles vaccines. PharmacoEconomics & Outcomes News, 825, 9-10