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NISH (NITAG Support Hub) 13: Typhoid Conjugate Vaccine (TCV) : Systematic Reviews

This Library Guide is a collection of useful documents & evidence on the safety, efficacy, effectiveness and impact of the Typhoid Conjugate Vaccine (TCV) to support NITAG members and other policy makers throughout Africa with making evidence-based recom

Systematic Reviews

Andrews, J. R., Baker, S., Marks, F., Alsan, M., Garrett, D., Gellin, B. G., Saha, S. K., Qamar, F. N., Yousafzai, M. T., & Bogoch, I. I. (2019). Typhoid conjugate vaccines: A new tool in the fight against antimicrobial resistance. The Lancet Infectious Diseases, 19(1), e26–e30. (NOT OA)

Batool, R., Qamar, Z. H., Salam, R. A., Yousafzai, M. T., Ashorn, P., & Qamar, F. N. (2024). Efficacy of typhoid vaccines against culture-confirmed Salmonella Typhi in typhoid endemic countries: A systematic review and meta-analysis. The Lancet Global Health, 12(4), e589–e598. https://www.thelancet.com/action/showPdf?pii=S2214-109X%2823%2900606-X

Birkhold, M., Mwisongo, A., Pollard, A. J., & Neuzil, K. M. (2021). Typhoid conjugate vaccines: Advancing the research and public health agendas. The Journal of Infectious Diseases, 224(Supplement_7), S781–S787. https://d1wqtxts1xzle7.cloudfront.net/112598093/jiab449-libre.pdf?1710961588=&response-content-disposition=inline%3B+filename%3DTyphoid_Conjugate_Vaccines_Advancing_the.pdf

Gloeck, N. R., Leong, T. D., Mthethwa, M., Iwu-Jaja, C. J., Katoto, P. D., Wiysonge, C. S., & Kredo, T. (2025). Typhoid conjugate vaccines for preventing typhoid fever (enteric fever). The Cochrane Database of Systematic Reviews, 2025(5), CD015746. doi: 10.1002/14651858.CD015746.pub2

Milligan, R., Paul, M., Richardson, M., & Neuberger, A. (2018). Vaccines for preventing typhoid fever. Cochrane Database of Systematic Reviews, 5. https://doi.org/10.1002/14651858.CD001261.pub4

Mogasale, V. V., Sinha, A., John, J., Farooqui, H. H., Ray, A., Chantler, T., Mogasale, V., Dhoubhadel, B. G., Edmunds, W. J., & Clark, A. (2024). Typhoid conjugate vaccine implementation in India: A review of supportive evidence. Vaccine: X, 21, 100568. https://doi.org/10.1016/j.jvacx.2024.100568

Mohamed Taha, A., Abouelmagd, K., Mahmoud, A. M., Elkasaby, M. H., Nguyen, D., Ahmed, R., Patel, P., Bonilla-Aldana, D. K., Luna, C., & Rodriguez-Morales, A. J. (2024). Safety and immunogenicity of Vi-diphtheria toxoid typhoid conjugate vaccine among children below 2 years: A systematic review and meta-analysis. Frontiers in Microbiology, 15, 1385834. https://doi.org/10.3389/fmicb.2024.1385834

Nampota-Nkomba, N., Carey, M. E., Jamka, L. P., Fecteau, N., & Neuzil, K. M. (2023). Using typhoid conjugate vaccines to prevent disease, promote health equity, and counter drug-resistant typhoid fever. 10(Supplement_1), S6–S12 https://doi.org/10.1093/ofid/ofad022.

Patel, P. D., Liang, Y., Meiring, J. E., Chasweka, N., Patel, P., Misiri, T., Mwakiseghile, F., Wachepa, R., Banda, H. C., & Shumba, F. (2024). Efficacy of typhoid conjugate vaccine: Final analysis of a 4-year, phase 3, randomised controlled trial in Malawian children. The Lancet, 403(10425), 459–468. https://www.thelancet.com/action/showPdf?pii=S0140-6736%2823%2902031-7

Shakya, M., & Pollard, A. J. (2024). Typhoid conjugate vaccines: A step towards typhoid control. The Lancet Global Health, 12(4), e535–e536. https://www.thelancet.com/action/showPdf?pii=S2214-109X%2824%2900055-X