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NISH (NITAG Support Hub) 15 : Hepatitis B Vaccine: Systematic Reviews

This Library Guide is a collection of useful documents & evidence on the safety, efficacy, effectiveness and impact of the Hepatitis B vaccine to support NITAG members and other policy makers throughout Africa with making evidence-based recomm

Systematic Reviews

 

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Wen, T., Dun, C., Hu, S., Pan, Q., Zhang, X., & Zhao, F. (2025). Ten-year evaluation of HPV vaccine influence on non-vaccine-type-related cervical infections and precancers in Chinese females: follow-up from a randomized control trial. Journal of the National Cancer Center. https://doi.org/10.1016/j.jncc.2025.07.003. (In press)

Kafeero, H. M., Sendagire, H., Ndagire, D., Walusansa, A., Kudamba, A., Muwanda, F., ... & Ocama, P. (2025). The epidemiology of hepatitis b virus infection in Uganda after two decades of vaccination: a meta-analysis and meta-regression. BMC Infectious Diseases, 25(1), 1174. https://doi.org/10.1186/s12879-025-11582-2

Ajuwon, B. I., Yujuico, I., Roper, K., Richardson, A., Sheel, M., & Lidbury, B. A. (2021). Hepatitis B virus infection in Nigeria: A systematic review and meta-analysis of data published between 2010 and 2019. BMC Infectious Diseases, 21(1), 1120.

Auta, A., Adewuyi, E. O., Kureh, G. T., Onoviran, N., & Adeloye, D. (2018). Hepatitis B vaccination coverage among health-care workers in Africa: A systematic review and meta-analysis. Vaccine, 36(32), 4851–4860.

Awoke, N., Mulgeta, H., Lolaso, T., Tekalign, T., Samuel, S., Obsa, M. S., & Olana, R. (2020). Full-dose hepatitis B virus vaccination coverage and associated factors among health care workers in Ethiopia: A systematic review and meta-analysis. PLoS One, 15(10), e0241226.

Bakker, M., Bunge, E. M., Marano, C., De Ridder, M., & De Moerlooze, L. (2016). Immunogenicity, effectiveness and safety of combined hepatitis A and B vaccine: A systematic literature review. Expert Review of Vaccines, 15(7), 829–851.

Geta, M., Mengistu, G., Yizengaw, E., Manyzewal, T., Hailu, A., & Woldeamanuel, Y. (2024). Efficacy and safety of therapeutic vaccines for the treatment of chronic hepatitis B: A systematic review and meta-analysis of randomized controlled trials update. Medicine, 103(35), e39344.

Geta, M., Yizengaw, E., & Manyazewal, T. (2024). Hepatitis B vaccine effectiveness among vaccinated children in Africa: A systematic review and meta-analysis. BMC Pediatrics, 24(1), 145.

Ghozy, S., Nam, N. H., Radwan, I., Karimzadeh, S., Tieu, T. M., Hashan, M. R., Abbas, A. S., Eid, P. S., Vuong, N. L., & Khang, N. V. (2020). Therapeutic efficacy of hepatitis B virus vaccine in treatment of chronic HBV infections: A systematic review and meta‐analysis. Reviews in Medical Virology, 30(3), e2089.

Ji, D., Pang, X., Shen, D., Liu, S., Goyal, H., & Xu, H. (2022). Global prevalence of occult hepatitis B: A systematic review and meta‐analysis. Journal of Viral Hepatitis, 29(5), 317–329.

Kamath, G. R., Shah, D. P., & Hwang, L.-Y. (2014). Immune response to hepatitis B vaccination in drug using populations: A systematic review and meta-regression analysis. Vaccine, 32(20), 2265–2274.

Kochhar, G. S., Mohan, B. P., Khan, S. R., Chandan, S., Kassab, L. L., Ponnada, S., Desai, A., Caldera, F., Dulai, P. S., & Farraye, F. A. (2021). Hepatitis-B vaccine response in inflammatory bowel disease patients: A systematic review and meta-analysis. Inflammatory Bowel Diseases, 27(10), 1610–1619.

Lee, J.-H., Hong, S., Im, J. H., Lee, J.-S., Baek, J. H., & Kwon, H. Y. (2020). Systematic review and meta-analysis of immune response of double dose of hepatitis B vaccination in HIV-infected patients. Vaccine, 38(24), 3995–4000.

Lim, S. G., Agcaoili, J., De Souza, N. N. A., & Chan, E. (2019). Therapeutic vaccination for chronic hepatitis B: a systematic review and meta‐analysis. Journal of Viral Hepatitis, 26(7), 803–817.

Machaira, M., Papaevangelou, V., Vouloumanou, E. K., Tansarli, G. S., & Falagas, M. E. (2015). Hepatitis B vaccine alone or with hepatitis B immunoglobulin in neonates of HBsAg+/HBeAg− mothers: A systematic review and meta-analysis. Journal of Antimicrobial Chemotherapy, 70(2), 396–404.

Machmud, P. B., Glasauer, S., Gottschick, C., & Mikolajczyk, R. (2021). Knowledge, vaccination status, and reasons for avoiding vaccinations against hepatitis B in developing countries: A systematic review. Vaccines, 9(6), 625.

Mouchet, J., Salvo, F., Raschi, E., Poluzzi, E., Antonazzo, I. C., De Ponti, F., & Begaud, B. (2018). Hepatitis B vaccination and the putative risk of central demyelinating diseases–a systematic review and meta-analysis. Vaccine, 36(12), 1548–1555.

Mulley, W. R., Le, S. T., & Ives, K. E. (2017). Primary seroresponses to double-dose compared with standard-dose hepatitis B vaccination in patients with chronic kidney disease: A systematic review and meta-analysis. Nephrology Dialysis Transplantation, 32(1), 136–143.

Opri, R., Veneri, D., Mengoli, C., & Zanoni, G. (2015). Immune response to Hepatitis B vaccine in patients with celiac disease: A systematic review and meta-analysis. Human Vaccines & Immunotherapeutics, 11(12), 2800–2805.

Qiu, J., Zhang, S., Feng, Y., Su, X., Cai, J., Chen, S., Liu, J., Huang, S., Huang, H., & Zhu, S. (2024). Efficacy and safety of hepatitis B vaccine: An umbrella review of meta-analyses. Expert Review of Vaccines, 23(1), 69–81.

Rahmani, A., Montecucco, A., Kusznir Vitturi, B., Debarbieri, N., Dini, G., & Durando, P. (2022). Long-term effectiveness of hepatitis B vaccination in the protection of healthcare students in highly developed countries: A systematic review and meta-analysis. Vaccines, 10(11), 1841.

Schillie, S. F., Spradling, P. R., & Murphy, T. V. (2012). Immune response of hepatitis B vaccine among persons with diabetes: A systematic review of the literature. Diabetes Care, 35(12), 2690.

Steffen, G., Sperle, I., Harder, T., Sarma, N., Beermann, S., Thamm, R., Bremer, V., Zimmermann, R., & Dudareva, S. (2021). Hepatitis B vaccination coverage in Germany: Systematic review. BMC Infectious Diseases, 21(1), 817.

Sulistina, D. R. (2022). Effectiveness of Hepatitis B vaccination on various populations: A systematic review. Asian Journal of Health Research, 1(2), 64–74.

Wang, H., Men, P., Xiao, Y., Gao, P., Lv, M., Yuan, Q., Chen, W., Bai, S., & Wu, J. (2019). Hepatitis B infection in the general population of China: A systematic review and meta-analysis. BMC Infectious Diseases, 19(1), 811.

Whitford, K., Liu, B., Micallef, J., Yin, J. K., Macartney, K., Van Damme, P., & Kaldor, J. M. (2018). Long-term impact of infant immunization on hepatitis B prevalence: A systematic review and meta-analysis. Bulletin of the World Health Organization, 96(7), 484.

Younossi, Z., Kochems, K., De Ridder, M., Curran, D., Bunge, E. M., & de Moerlooze, L. (2017). Should adults with diabetes mellitus be vaccinated against hepatitis B virus? A systematic review of diabetes mellitus and the progression of hepatitis B disease. Human Vaccines & Immunotherapeutics, 13(11), 2695–2706.