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NISH (NITAG Support Hub) 9: MMR Vaccine with a Specific Focus on Mumps: Policy Question, PICO and Search Strategy

Policy Question, PICO and Search Strategy


Policy Question: Should the mumps vaccine be offered to infants at 9 and 18 months in the routine immunization program in Lesotho? In infants at the age of 9 and 18 months, what is the scientific evidence that the mumps vaccine given in combination with the measles and rubella antigen is safe and prevents transmission of the mumps virus

PICO

Population - children 9-18 months

 Intervention – mumps vaccine

Comparison- no vaccine

Outcome- reduction in transmission, mortality, morbidity, safety

Search strategy for PubMed

(measles mumps rubella vaccine[Text Word] OR measles- mumps-rubella vaccine[Text Word] OR MMR vaccine[Text Word] OR measles mumps rubella vaccination[Text Word] OR measles- mumps-rubella vaccination[Text Word] OR MMR vaccination[Text Word] OR measles mumps rubella varicella vaccine[Text Word] OR measles- mumps- rubella- varicella vaccine[Text Word] OR measles mumps rubella varicella vaccination[Text Word] OR measles- mumps- rubella- varicella vaccination[Text Word] OR MMRV vaccination[Text Word]) AND (Infant[Text Word] OR infants[Text Word] OR child[Text Word] OR children[Text Word]) (measles mumps rubella vaccine[Text Word] OR measles- mumps-rubella vaccine[Text Word] OR MMR vaccine[Text Word] OR measles mumps rubella vaccination[Text Word] OR measles- mumps-rubella vaccination[Text Word] OR MMR vaccination[Text Word] OR measles mumps rubella varicella vaccine[Text Word] OR measles- mumps- rubella- varicella vaccine[Text Word] OR measles mumps rubella varicella vaccination[Text Word] OR measles- mumps- rubella- varicella vaccination[Text Word] OR MMRV vaccination[Text Word]) AND (Infant[Text Word] OR infants[Text Word] OR child[Text Word] OR children[Text Word])

Filters for Search strategy 1: LMICs; 10 years

Filters: for Search strategy 2 : LMICs + South America - Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Guyana, Paraguay, Peru, Suriname, Uruguay, and Venezuela

Filters: for Search strategy 3: only date 10 years