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NISH (NITAG Support Hub) 3: Malaria vaccines: Subsaharan countries

This Library Guide is a collection of useful documents & evidence on the efficacy, effectiveness and impact of the RTS,S/AS01 malaria vaccine to support NITAG members and other policy makers throughout Africa with making evidence-based recommendations.

Latest articles

Aiman, U., Azad, Z., & Awais, A. R. (2024). Unveiling Malaria's Silent Threat: From Socioeconomic Divides to Religious Influences, A Path to Effective Prevention in India. Journal of vector borne diseases, 10.4103/0972-9062.393978. Advance online publication.            DOI: 10.4103/0972-9062.393978

Takashima, E., Otsuki, H., Morita, M., Ito, D., Nagaoka, H., Yuguchi, T., Hassan, I., & Tsuboi, T. (2024). The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for Plasmodium falciparumBiomolecules14(1)    DOI: 10.3390/biom14010100

Datoo, M. S., Dicko, A., Tinto, H., Ouédraogo, J. B., Hamaluba, M., Olotu, A., Beaumont, E., Ramos Lopez, F., Natama, H. M., Weston, S., Chemba, M., Compaore, Y. D., Issiaka, D., Salou, D., Some, A. M., Omenda, S., Lawrie, A., Bejon, P., Rao, H., Chandramohan, D., … R21/Matrix-M Phase 3 Trial Group (2024). Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial. Lancet (London, England)403(10426), 533–544. DOI: 10.1016/S0140-6736(23)02511-4

Schmit, N., Topazian, H. M., Natama, H. M., Bellamy, D., Traoré, O., Somé, M. A., Rouamba, T., Tahita, M. C., Bonko, M. D. A., Sourabié, A., Sorgho, H., Stockdale, L., Provstgaard-Morys, S., Aboagye, J., Woods, D., Rapi, K., Datoo, M. S., Lopez, F. R., Charles, G. D., McCain, K., … Winskill, P. (2024). The public health impact and cost-effectiveness of the R21/Matrix-M malaria vaccine: a mathematical modelling study. The Lancet. Infectious diseases24(5), 465–475. DOI: 10.1016/S1473-3099(23)00816-2

Chutiyami, M., Saravanakumar, P., Bello, U. M., Salihu, D., Adeleye, K., Kolo, M. A., Dawa, K. K., Hamina, D., Bhandari, P., Sulaiman, S. K., & Sim, J. (2024). Malaria vaccine efficacy, safety, and community perception in Africa: a scoping review of recent empirical studies. Infection, 10.1007/s15010-024-02196-y. Advance online publication.  DOI: 10.1007/s15010-024-02196-y

Li, J., Docile, H. J., Fisher, D., Pronyuk, K., & Zhao, L. (2024). Current Status of Malaria Control and Elimination in Africa: Epidemiology, Diagnosis, Treatment, Progress and Challenges. Journal of epidemiology and global health, 10.1007/s44197-024-00228-2. Advance online publication.  DOI: 10.1007/s44197-024-00228-2

Senkpeil, L., Bhardwaj, J., Little, M. R., Holla, P., Upadhye, A., Fusco, E. M., Swanson, P. A., 2nd, Wiegand, R. E., Macklin, M. D., Bi, K., Flynn, B. J., Yamamoto, A., Gaskin, E. L., Sather, D. N., Oblak, A. L., Simpson, E., Gao, H., Haining, W. N., Yates, K. B., Liu, X., … Tran, T. M. (2024). Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine. JCI insight9(11), e167408.   DOI: 10.1172/jci.insight.167408

Tajudeen YA, Oladipo HJ, Yusuff SI, Abimbola SO, Abdulkadir M, Oladunjoye IO, Omotosho AO, Egbewande OM, Shittu HD, Yusuf RO, Ogundipe O, Muili AO, Afolabi AO, Dahesh SMA, Gameil MAM, El-Sherbini MS. (2024). A landscape review of malaria vaccine candidates in the pipeline. Trop Dis Travel Med Vaccines.;10(1):19. doi: 10.1186/s40794-024-00222-3. PMID: 39085983.

Duffy PE, Gorres JP, Healy SA, Fried M. (2024) Malaria vaccines: a new era of prevention and control. Nat Rev Microbiol.  DOI: 10.1038/s41579-024-01065-7 . Epub ahead of print. PMID: 39025972.

Lawal L, Buhari AO, Jaji TA, Alatare AS, Adeyemo AO, Olumoh AO, Yusuff YA, Osborn G, Mogaji AB, Adoto BH, Ibrahim NG, Saliu WO, Abdul-Rahman T. Lingering challenges in malaria elimination efforts in sub-Saharan Africa: Insights and potential solutions. Health Sci Rep. ;7(6):e2122.  DOI: 10.1002/hsr2.2122

Khan, S., Patel, M. P., Patni, A. D., & Cha, S. J. (2024). Targeting Plasmodium Life Cycle with Novel Parasite Ligands as Vaccine Antigens. Vaccines12(5), 484.   DOI: 10.3390/vaccines12050484

Hamilton, A., Haghpanah, F., Hasso-Agopsowicz, M., Frost, I., Lin, G., Schueller, E., Klein, E., & Laxminarayan, R. (2023). Modeling of malaria vaccine effectiveness on disease burden and drug resistance in 42 African countries. Communications medicine3(1), 144.  DOI: 10.1038/s43856-023-00373-y

Okoth, W. A., Ho, M.-F., Zaman, M., Cooper, E., Som, P., Burgess, M., Walton, M., Nevagi, R. J., Beattie, L., Murphy, D., Stanisic, D. I., & Good, M. F. (2023). A CAF01-adjuvanted whole asexual blood-stage liposomal malaria vaccine induces a CD4+ T-cell-dependent strain-transcending protective immunity in rodent models. mBio14(6)  DOI: 10.1128/mbio.02547-23

Juraska, M., Early, A. M., Li, L., Schaffner, S. F., Lievens, M., Khorgade, A., Simpkins, B., Hejazi, N. S., Benkeser, D. A., Wang, Q., Mercer, L. D., Adjei, S., Agbenyega, T., Anderson, S., Ansong, D., Bii, D. K., Buabeng, P. B. Y., English, S., Fitzgerald, N., Grimsby, J., … Neafsey, D. E. (2023). Baseline malaria infection status and RTS,S/AS01E malaria vaccine efficacy. medRxiv : the preprint server for health sciences. DOI: 10.1101/2023.11.22.23298907

Borkens Y. (2023). Malaria & mRNA Vaccines: A Possible Salvation from One of the Most Relevant Infectious Diseases of the Global South. Acta parasitologica68(4), 916–928. DOI: 10.1007/s11686-023-00712-y

Stanisic, D. I., & Good, M. F. (2023). Malaria Vaccines: Progress to Date. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy37(6), 737–756. DOI: 10.1007/s40259-023-00623-4

Rts, S.C.T.P., 2015. Efficacy and safety of RTS, S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. The Lancet, 386(9988), pp.31-45. doi: 10.1016/S0140-6736(15)60721-8 OR https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626001/ OR https://www.nitag-resource.org/sites/default/files/2022-05/PIIS1473309919303007.pdf OR DOI: 10.1016/S1473-3099(19)30300-7

Hogan, A.B., Winskill, P. and Ghani, A.C., 2020. Estimated impact of RTS, S/AS01 malaria vaccine allocation strategies in sub-Saharan Africa: a modelling study. PLoS Medicine17(11), p.e1003377.  https://doi.org/10.1371/journal.pmed.1003377

World Health Organization. 2022. Q & A on the RTS,S malaria vaccine, the WHO vaccine recommendation and next steps
 
Villanueva, G., Henschke, N., Hamel, C. and Buckley, B., Annex 9a: Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) Evidence summary table. RTS1, p.1.
 
Rts, S.C.T.P., 2015. Efficacy and safety of RTS, S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. The Lancet386(9988), pp.31-45. doi: 10.1016/S0140-6736(15)60721-8

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626001/

Mosquirix: Opinion on medicine for use outside EU. European Medicines Agency – 2015.https://www.ema.europa.eu/en/opinion-medicine-use-outside-EU/human/mosqu

PATH, Liverpool School of Tropical Medicine (Kenya), Malawi-Liverpool Wellcome Trust (Malawi), & University of Health and Allied Sciences (Ghana). (2022). Health Utilisation Study (HUS) Round 2 - cross-country report on findings from the Primary Child Caregiver cohort sample. Zenodo. https://doi.org/10.5281/zenodo.6395820

Chandramohan, D., Zongo, I., Sagara, I., Cairns, M., Yerbanga, R.S., Diarra, M., Nikiema, F., Tapily, A., Sompougdou, F., Issiaka, D. and Zoungrana, C., 2021. Seasonal malaria vaccination with or without seasonal malaria chemoprevention. New England Journal of Medicine385(11), pp.1005-1017. DOI: 10.1056/NEJMoa2026330

Tinto, H., Otieno, W., Gesase, S., Sorgho, H., Otieno, L., Liheluka, E., Valéa, I., Sing'oei, V., Malabeja, A., Valia, D. and Wangwe, A., 2019. Long-term incidence of severe malaria following RTS, S/AS01 vaccination in children and infants in Africa: an open-label 3-year extension study of a phase 3 randomised controlled trial. The Lancet Infectious Diseases19(8), pp.821-832.                                                                                          https://www.nitag-resource.org/sites/default/files/2022-05/PIIS1473309919303007.pdf    OR  DOI: 10.1016/S1473-3099(19)30300-7

Rts, S.C.T.P., 2015. Efficacy and safety of RTS, S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. The Lancet, 386(9988), pp.31-45. doi: 10.1016/S0140-6736(15)60721-8 OR https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626001/