In evidence-based medicine, clinical decision-making is based on the integration of individual expertise, the best available evidence from systematic research and the needs and values of the patient. A systematic review includes a comprehensive search for primary studies on a particular clinical question, the critical evaluation of these studies and a synthesis of results according to a pre-determined methodology which may include meta-analyses of data. PubMed Health have produced a useful introduction, What is a Systematic Review?
The Campbell Collaboration prepares, maintains and disseminates systematic reviews in education, crime and justice, and social welfare. This includes a library of systematic reviews and review templates.
Rapid reviews are similar to systematic reviews in their attempt at answering a clinical question to inform decision-making. However, the rapid review has a much shorter time frame, fewer databases are searched and there is often limited or no hand searching or grey literature searching done. This would increase the risk of bias.