Skip to Main Content

NISH (NITAG Support Hub) 3: Malaria vaccines: Systematic Reviews

This Library Guide is a collection of useful documents & evidence on the efficacy, effectiveness and impact of the RTS,S/AS01 malaria vaccine to support NITAG members and other policy makers throughout Africa with making evidence-based recommendations.

Systematic Reviews

 
Zoa, J. A., Njemguie Linjouom, R. M., Nyangono Ndongo, M., & Nkeck, J. R. (2025). Safety of RTS,S/AS01E vaccine for malaria in African children aged 5 to 17 months: A systematic review and meta-analysis of randomized controlled trials. PLOS global public health, 5(6), e0004387. https://doi.org/10.1371/journal.pgph.0004387

Hamisi, M. A., Asri, N. A. M., Yassim, A. S. M., & Suppian, R. (2025). A systematic review on malaria and Tuberculosis (TB) vaccine challenges in sub-Saharan African clinical trials. PLoS One, 20(1), e0317233.
https://doi.org/10.1371/journal.pone.0317233

Yihunie, W., Kebede, B., Tegegne, B.A., Getachew, M., Abebe, D., Aschale, Y., Belew, H. and Bahiru, B., 2023. Systematic Review of Safety of RTS, S with AS01 and AS02 Adjuvant Systems Using Data from Randomized Controlled Trials in Infants, Children, and Adults. Clinical Pharmacology: Advances and Applications, pp.21-32.     https://www.tandfonline.com/doi/full/10.2147/CPAA.S400155

Sulaiman, S.K., Musa, M.S., Tsiga-Ahmed, F.I., Dayyab, F.M., Sulaiman, A.K. and Bako, A.T., 2022. A systematic review and meta-analysis of the prevalence of caregiver acceptance of malaria vaccine for under-five children in low-income and middle-income countries (LMICs). Plos one17(12), p.e0278224.   https://doi.org/10.1371/journal.pone.0278224

Takashima, E., Kanoi, B.N., Nagaoka, H., Morita, M., Hassan, I., Palacpac, N.M., Egwang, T.G., Horii, T., Gitaka, J. and Tsuboi, T., 2022. Meta-Analysis of Human Antibodies Against Plasmodium falciparum Variable Surface and Merozoite Stage Antigens. Frontiers in Immunology13, p.887219. https://doi.org/10.3389/fimmu.2022.887219

Oguike, O.E., Ugwuishiwu, C.H., Asogwa, C.N., Nnadi, C.O., Obonga, W.O. and Attama, A.A., 2022. Systematic review on the application of machine learning to quantitative structure–activity relationship modeling against Plasmodium falciparum. Molecular Diversity26(6), pp.3447-3462. (NOT OA)

Shibeshi, W., Bagchus, W., Yalkinoglu, Ö., Tappert, A., Engidawork, E. and Oeuvray, C., 2021. Reproducibility of malaria sporozoite challenge model in humans for evaluating efficacy of vaccines and drugs: a systematic review. BMC Infectious Diseases21(1), pp.1-15. https://doi.org/10.1186/s12879-021-06953-4https://doi.org/10.1186/s12879-021-06953-4

Banda, G.T., Deribe, K. and Davey, G., 2021. How can we better integrate the prevention, treatment, control and elimination of neglected tropical diseases with other health interventions? A systematic review. BMJ Global Health6(10), p.e006968. DOI: 10.1136/bmjgh-2021-006968

Muthui, M.K., Kamau, A., Bousema, T., Blagborough, A.M., Bejon, P. and Kapulu, M.C., 2019. Immune responses to gametocyte antigens in a malaria endemic population—the African falciparum context: a systematic review and meta-analysis. Frontiers in immunology10, p.2480. DOI: 10.3389/fimmu.2019.02480

Matangila, J.R., Mitashi, P., Inocêncio da Luz, R.A., Lutumba, P.T. and Van Geertruyden, J.P., 2015. Efficacy and safety of intermittent preventive treatment for malaria in schoolchildren: a systematic review. Malaria journal14, pp.1-12.   DOI: 10.1186/s12936-015-0988-5

Mbuagbaw, L., Medley, N., Darzi, A.J., Richardson, M., Garga, K.H. and Ongolo‐Zogo, P., 2015. Health system and community level interventions for improving antenatal care coverage and health outcomes. Cochrane Database of Systematic Reviews, (12).  DOI: 10.1002/14651858.CD010994.pub2

Cutts, J.C., Agius, P.A., Lin, Z., Powell, R., Moore, K., Draper, B., Simpson, J.A. and Fowkes, F.J., 2020. Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review. BMC medicine18, pp.1-21 https://link.springer.com/article/10.1186/s12916-019-1467-6
 

Brew, J. and Sauboin, C., 2019. A systematic review of the incremental costs of implementing a new vaccine in the expanded program of immunization in sub-Saharan AfricaMDM Policy & Practice4(2), p.2381468319894546. https://doi.org/10.1177/2381468319894546

Githang'a, D., Anzala, O., Mutegi, C. and Agweyu, A., 2019. The effects of exposures to mycotoxins on immunity in children: A systematic review. Current problems in pediatric and adolescent health care49(5), pp.109-116. (NOT OA)

Dimala, C.A., Kika, B.T., Kadia, B.M. and Blencowe, H., 2018. Current challenges and proposed solutions to the effective implementation of the RTS, S/AS01 Malaria Vaccine Program in sub-Saharan Africa: A systematic review. PloS one13(12), p.e0209744. DOI: 10.1371/journal.pone.0209744

Degarege, A., Gebrezgi, M.T., Ibanez, G., Wahlgren, M. and Madhivanan, P., 2019. Effect of the ABO blood group on susceptibility to severe malaria: a systematic review and meta-analysis. Blood reviews33, pp.53-62. (NOT OA)

Brickley, E.B., Coulibaly, M., Gabriel, E.E., Healy, S.A., Hume, J.C., Sagara, I., Traore, S.F., Doumbo, O. and Duffy, P.E., 2016. Utilizing direct skin feeding assays for development of vaccines that interrupt malaria transmission: a systematic review of methods and case study. Vaccine34(48), pp.5863-5870. DOI: 10.1016/j.vaccine.2016.10.027

Agnandji, S.T., Fernandes, J.F., Bache, E.B. and Ramharter, M., 2015. Clinical development of RTS, S/AS malaria vaccine: a systematic review of clinical Phase I–III trials. Future microbiology10(10), pp.1553-1578. (NOT OA)