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NISH (NITAG Support Hub) 2: Covid-19 vaccine hesitancy/confidence in Africa Latest Systematic Reviews: Vaccine hesitancy in general Sub-Saharan Africa

This Library Guide contains published and unpublished information on vaccine hesitancy and related issues in the context of COVID-19 vaccination in Subsaharan Africa

Latest research articles : Sub-Sahara

Adeyanju, G. C., Essoh, T.-A., Sidibe, A. R., Kyesi, F., & Aina, M. (2024). Human Papillomavirus Vaccination Acceleration and Introduction in Sub-Saharan Africa: A Multi-Country Cohort Analysis. Vaccines, 12(5). https://doi.org/10.3390/vaccines12050489

de Figueiredo, A., Temfack, E., Tajudeen, R., & Larson, H. J. (2023). Declining trends in vaccine confidence across sub-Saharan Africa: A large-scale cross-sectional modeling study. Human Vaccines & Immunotherapeutics, 19(1), 2213117. https://doi.org/10.1080/21645515.2023.2213117

Ghazy, R. M., Gebreal, A., Saleeb, M. R. A., Sallam, M., El-Deen, A. E.-S. N., Sheriff, S. D., Tessema, E. A., Ahurwendeire, S., Tsoeu, N., Chamambala, P. C., Cibangu, P. B., Okeh, D. U., Traoré, A. S., Eshun, G., Kengo, N. E., Kubuka, A. E., Awuah, L. B., Salah, A., Aljohani, M., & Fadl, N. (2024). Compulsory Vaccination Coverage in 12 Sub-Saharan African Countries Two Years Following the COVID-19 Pandemic. Journal of Community Health, 49(2), 193–206. https://doi.org/10.1007/s10900-023-01261-1

Udoakang, A. J., Nganyewo, N. N., Djomkam Zune, A. L., Olwal, C. O., Etim, N.-A. A., Oboh, M. A., Tapela, K., Dzabeng, F., Adadey, S. M., Udoh, A., Koné, M., Mutungi, J. K., Quashie, P. K., Awandare, G. A., & Paemka, L. (2024). Knowledge, attitude and perception towards COVID-19 among representative educated sub-Saharan Africans: A cross-sectional study during the exponential phase of the  pandemic. PloS One, 19(2), e0281342. https://doi.org/10.1371/journal.pone.0281342

Unfried, K., & Priebe, J. (2024). Vaccine hesitancy and trust in sub-Saharan Africa. Scientific Reports, 14(1), 10860. https://doi.org/10.1038/s41598-024-61205-0

Wollburg, P., Markhof, Y., Kanyanda, S., & Zezza, A. (2023). Assessing COVID-19 vaccine hesitancy and barriers to uptake in Sub-Saharan Africa. Communications Medicine, 3(1), 121. https://doi.org/10.1038/s43856-023-00330-9

Wollburg, P., Markhof, Y., Kanyanda, S., & Zezza, A. (2023). Assessing COVID-19 vaccine hesitancy and barriers to uptake in Sub-Saharan Africa. Communications Medicine, 3(1), 121. https://doi.org/10.1038/s43856-023-00330-9
 
Gudayu, T.W. and Mengistie, H.T., 2023. COVID-19 vaccine acceptance in sub-Saharan African countries: a systematic review and meta-analysis. Heliyon, 9(2). DOI: 10.1016/j.heliyon.2023.e13037
 
Sallam, M., 2021. COVID-19 vaccine hesitancy worldwide: a concise systematic review of vaccine acceptance rates. Vaccines, 9(2), p.160. https://doi.org/10.3390/vaccines9020160
 
Bobrovitz, N., Arora, R.K., Cao, C., Boucher, E., Liu, M., Donnici, C., Yanes-Lane, M., Whelan, M., Perlman-Arrow, S., Chen, J. and Rahim, H., 2021. Global seroprevalence of SARS-CoV-2 antibodies: a systematic review and meta-analysis. PloS one, 16(6), p.e0252617. https://doi.org/10.1371/journal.pone.0252617
 
Kutz, J.M., Rausche, P., Gheit, T., Puradiredja, D.I. and Fusco, D., 2023. Barriers and facilitators of HPV vaccination in sub-saharan Africa: a systematic review. BMC Public Health, 23(1), p.974. https://doi.org/10.1186/s12889-023-15842-1
 
Ochola, E.A., 2023. Vaccine hesitancy in Sub-Saharan Africa in the Context of COVID-19 vaccination exercise: a systematic review. Diseases, 11(1), p.32.  https://doi.org/10.3390/diseases11010032
 
Kigongo, E., Kabunga, A., Tumwesigye, R., Musinguzi, M., Izaruku, R. and Acup, W., 2023. Prevalence and predictors of COVID-19 vaccination hesitancy among healthcare workers in Sub-Saharan Africa: A systematic review and meta-analysis. PLoS One, 18(7), p.e0289295.https://doi.org/10.1371/journal.pone.0289295
 

 

 

WHO Africa

World Health Organization (WHO), 2021. Risks and challenges in Africa’s COVID-19 vaccine rollout. 2021e.
https://www.afro.who.int/news/risks-and-challenges-africas-covid-19-vaccine-rollout

 

Opening statement, COVID-19 Press Conference, 25 November ...                                                                                                                                                                              https://www.afro.who.int/regional-director/speeches-messages/opening-statement-covid-19-press-conference-25-november-2021

PERC, 2020. Responding to COVID-19 in Africa: Using Data to Find a Balance.
https://www.afro.who.int/sites/default/files/2020-09/PERC_RespondingtoCovidData.pdf
 
WHO Regional Office for Africa. 2022. Covid-19 vaccination the in the WHO African region. WHO Monthly Bulletin.
COVID-19 VACCINATION IN THE WHO AFRICAN REGION
Twenty priority countries, at high risk of slow COVID-19 vaccination roll out, have been identified for this initiative. WHO AFRO has already deployed 30 experts in 18 out of the 20 priority countries. Six countries out of the 20 priority countries (Côte d’Ivoire, Ethiopia, Ghana, DR Congo,Guinea Bissau and Kenya) have started to implement phased vaccination campaigns to ramp up COVID-vaccination rates.
Overall, the number of doses administered in the African region increased by 23% in February 2022 compared to January 2022.
 
WHO Africa. 2021. Key lessons from Africa's COVID-19 vaccine rollout. 2021.
“Fighting misinformation that fuels vaccine hesitancy is by no means easy,” says Dr Gilson Paluku, an Immunization Officer...
https://www.afro.who.int/news/key-lessons-africas-covid-19-vaccine-rollout
 
WHO Africa. 2021. Frontline Health workers in Hoima District (Uganda) Hesitate about COVID-19 vaccination, then Embrace it after WHO Assurance - April 2021.
https://www.afro.who.int/pt/node/14420
 
WHO Africa. April 2021. Less than 2% of world’s COVID-19 vaccines administered in Africa.
https://www.afro.who.int/news/less-2-worlds-covid-19-vaccines-administered-africa
 

 

Immunopaedia

Lustig, Y., Nemet, I., Kliker, L., Zuckerman, N., Yishai, R., Alroy-Preis, S., Mendelson, E. and Mandelboim, M., 2021. Neutralizing response against variants after SARS-CoV-2 infection and one dose of BNT162b2. New England Journal of Medicine, 384(25), pp.2453-2454. (Not OA)

Pubmed : Covid-19 AND "vaccination hesitancy" AND Africa

Liu, Y., Procter, S.R., Pearson, C.A., Montero, A.M., Torres-Rueda, S., Asfaw, E., Uzochukwu, B., Drake, T., Bergren, E., Eggo, R.M. and Ruiz, F., 2023. Assessing the impacts of COVID-19 vaccination programme’s timing and speed on health benefits, cost-effectiveness, and relative affordability in 27 African countries. BMC medicine, 21(1), pp.1-15.

https://doi.org/10.1186/s12916-023-02784-z

Cardoso Pinto, A.M., Shariq, S., Ranasinghe, L., Sundar Budhathoki, S., Skirrow, H., Whittaker, E. and Seddon, J.A., 2023. Reasons for reductions in routine childhood immunisation uptake during the COVID-19 pandemic in low-and middle-income countries: A systematic review. PLOS Global Public Health, 3(1), p.e0001415.

https://doi.org/10.1371/journal.pgph.0001415

Onyeaghala, A.A., Anyiam, A.F., Husaini, D.C., Onyeaghala, E.O. and Obi, E., 2023. Herbal supplements as treatment options for COVID-19: A call for clinical development of herbal supplements for emerging and re-emerging viral threats in Sub-Saharan Africa. Scientific African, 20, p.e01627.

https://doi.org/10.1016/j.sciaf.2023.e01627

Couch, M.A., Katoto, P.D., Cinini, S.F. and Wiysonge, C.S., 2023. Integrating civil liberty and the ethical principle of autonomy in building public confidence to reduce COVID-19 vaccination inequity in Africa. Human Vaccines & Immunotherapeutics, 19(1), p.2179789.

https://doi.org/10.1080/21645515.2023.2179789

Amiebenomo, O.M., Osuagwu, U.L., Envuladu, E.A., Miner, C.A., Mashige, K.P., Ovenseri-Ogbomo, G., Abu, E.K., Timothy, C.G., Ekpenyong, B.N., Langsi, R. and Oloruntoba, R., 2023. Acceptance and Risk Perception of COVID-19 Vaccination among Pregnant and Non Pregnant Women in Sub-Saharan Africa: A Cross-Sectional Matched-Sample Study. Vaccines, 11(2), p.484.

https://doi.org/10.3390/vaccines11020484

Montcho, Y., Nalwanga, R., Azokpota, P., Doumatè, J.T., Lokonon, B.E., Salako, V.K., Wolkewitz, M. and Glèlè Kakaï, R., 2023. Assessing the Impact of Vaccination on the Dynamics of COVID-19 in Africa: A Mathematical Modeling Study. Vaccines, 11(4), p.857.

https://doi.org/10.3390/vaccines11040857

Naidoo, D., Meyer-Weitz, A. and Govender, K., 2023. Factors Influencing the Intention and Uptake of COVID-19 Vaccines on the African Continent: A Scoping Review. Vaccines, 11(4), p.873.

https://doi.org/10.3390/vaccines11040873

Miner, C.A., Timothy, C.G., Percy, K. et al. Acceptance of COVID-19 vaccine among sub-Saharan Africans (SSA): a comparative study of residents and diasporan dwellers. BMC Public Health 23, 191 (2023). https://doi.org/10.1186/s12889-023-15116-w

https://link.springer.com/article/10.1186/s12889-023-15116-w#citeas

Ochola, E.A., 2023. Vaccine Hesitancy in Sub-Saharan Africa in the Context of COVID-19 Vaccination Exercise: A Systematic Review. Diseases, 11(1), p.32.
https://doi.org/10.3390/diseases1101003
 
Gudayu, T.W. and Mengistie, H.T., 2023. COVID-19 vaccine acceptance in sub-Saharan African countries: A systematic review and meta-analysis. Heliyon, p.e13037.
https://doi.org/10.1016/j.heliyon.2023.e13037
 
Abu El Kheir-Mataria, W., Saleh, B.M., El-Fawal, H. and Chun, S., 2023. COVID-19 vaccine hesitancy among parents in Low-and Middle-Income Countries: A meta-analysis. Frontiers in Public Health, 11, p.417.
https://doi.org/10.3389/fpubh.2023.1078009
 
Naidoo, D., Meyer-Weitz, A. and Govender, K., 2023. Factors Influencing the Intention and Uptake of COVID-19 Vaccines on the African Continent: A Scoping Review. Vaccines, 11(4), p.873.
 https://doi.org/10.3390/vaccines11040873
 
Ukwishaka, J., Ndayishimiye, Y., Destine, E., Danwang, C. and Kirakoya-Samadoulougou, F., 2023. Global prevalence of coronavirus disease 2019 reinfection: a systematic review and meta-analysis. BMC Public Health, 23(1), pp.1-20.
https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-023-15626-7
 
Osuagwu, U.L., Mashige, K.P., Ovenseri-Ogbomo, G., Envuladu, E.A., Abu, E.K., Miner, C.A., Timothy, C.G., Ekpenyong, B.N., Langsi, R., Amiebenomo, O.M. and Oloruntoba, R., 2023. The impact of information sources on COVID-19 vaccine hesitancy and resistance in sub-Saharan Africa. BMC Public Health, 23(1), p.38.
DOI: 10.1186/s12889-022-14972-2
 

World Health Organization, 2022. COVID-19 response for Africa-monthly bulletin: situation and response actions in the African Region, October 2022. COVID-19 response for Africa-monthly bulletin, (8), pp.1-24.

https://apps.who.int/iris/bitstream/handle/10665/364319/IMST-COVID1920228-eng.pdf?sequence=1

Wang, D., Chukwu, A., Mwanyika-Sando, M., Abubakari, S.W., Assefa, N., Madzorera, I., Hemler, E.C., Ismail, A., Lankoande, B., Mapendo, F. and Millogo, O., 2022. COVID-19 vaccine hesitancy and its determinants among sub-Saharan African adolescents. PLOS Global Public Health, 2(10), p.e0000611

https://doi.org/10.1371/journal.pgph.0000611

Njoga, E.O., Awoyomi, O.J., Onwumere-Idolor, O.S., Awoyomi, P.O., Ugochukwu, I.C. and Ozioko, S.N., 2022. Persisting Vaccine Hesitancy in Africa: The Whys, Global Public Health Consequences and Ways-Out—COVID-19 Vaccination Acceptance Rates as Case-in-Point. Vaccines, 10(11), p.1934.

https://doi.org/10.3390/vaccines10111934

Goldenberg, R.L., Naqvi, S., Saleem, S. and McClure, E., 2022. Variability in COVID‐19 vaccination rates in pregnant women: Vaccine hesitancy or supply limitations?. Bjog.
doi: 10.1111/1471-0528.17257 (Preprint)
 
Deml, M.J. and Githaiga, J.N., 2022. Determinants of COVID-19 vaccine hesitancy and uptake in sub-Saharan Africa: a scoping review. BMJ Open, 12(11), p.e066615.
http://dx.doi.org/10.1136/bmjopen-2022-066615
 
Azanaw, J., Endalew, M., Zenbaba, D., Abera, E. and Chattu, V.K., 2022. COVID-19 vaccine acceptance and associated factors in 13 African countries: A systematic review and meta-analysis. Frontiers in public health, 10.
doi: 10.3389/fpubh.2022.1001423
 
Sallam, M., Al-Sanafi, M. and Sallam, M., 2022. A global map of COVID-19 vaccine acceptance rates per country: an updated concise narrative review. Journal of Multidisciplinary Healthcare, 15, p.21.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760993/

Mutombo PN, Fallah MP, Munodawafa D, Kabel A, Houeto D, Goronga T, Mweemba O, Balance G, Onya H, Kamba RS, Chipimo M, Kayembe JN, Akanmori B. COVID-19 vaccine hesitancy in Africa: a call to action. Lancet Glob Health. 2022 Mar;10(3):e320-e321. doi: 10.1016/S2214-109X(21)00563-5. Epub 2021 Dec 20. PMID: 34942117; PMCID: PMC8687664.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687664/

Taylor-Robinson, S.D., Morgan, M.Y., Spearman, C.W., Suliman, A.A., Corrah, T., Oleribe, O.O. and Taylor-Robinson, A.W., 2022. Why SARS-CoV-2 vaccination still matters in Africa. QJM: An International Journal of Medicine, 115(3), pp.191-192. (Not OA)
 
Greyling T, Rossouw S (2022) Positive attitudes towards COVID-19 vaccines: A cross-country analysis. PLoS ONE 17(3): e0264994. https://doi.org/10.1371/journal.pone.0264994

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0264994

Amponsah, S.K., Tagoe, B. and Afriyie, D.K., 2021. Possible future trajectory of COVID-19: emphasis on Africa. The Pan African Medical Journal, 40.

https://www.panafrican-med-journal.com/content/article/40/157/full/

Kanyanda, S., Markhof, Y., Wollburg, P. and Zezza, A., 2021. Acceptance of COVID-19 vaccines in sub-Saharan Africa: Evidence from six national phone surveys. BMJ open, 11(12), p.e055159.
http://dx.doi.org/10.1136/bmjopen-2021-055159
 

Anjorin, A.A., Odetokun, I.A., Abioye, A.I., Elnadi, H., Umoren, M.V., Damaris, B.F., Eyedo, J., Umar, H.I., Nyandwi, J.B., Abdalla, M.M. and Tijani, S.O., 2021. Will Africans take COVID-19 vaccination?. PloS one, 16(12), p.e0260575.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260575

Wirsiy, F.S., Nkfusai, C.N., Ako-Arrey, D.E., Dongmo, E.K., Manjong, F.T. and Cumber, S.N., 2021. Acceptability of COVID-19 vaccine in Africa. International Journal of Maternal and Child Health  10(1), p.134.

https://www.mchandaids.org/index.php/IJMA/article/view/482

Noushad, M., Rastam, S., Nassani, M.Z., Al-Saqqaf, I.S., Hussain, M., Yaroko, A.A., Arshad, M., Kirfi, A.M., Koppolu, P., Niazi, F.H. and Elkandow, A., 2021. A Global Survey of COVID-19 Vaccine Acceptance Among Healthcare Workers. Frontiers in Public Health, 9.
https://www.frontiersin.org/articles/10.3389/fpubh.2021.794673/full
 
Mmadu-Okoli C, Nsofor Ifeanyi. 2021 WhatsApp, COVID-19 related misinformation in Africa and the need for continuous infoveillance. HPHR. 2021;39. 10.54111/0001/MM8
https://hphr.org/39-article-mmadu-okoli/
 
Ekwebelem, O.C., Yunusa, I., Onyeaka, H., Ekwebelem, N.C. and Nnorom-Dike, O., 2021. COVID-19 vaccine rollout: will it affect the rates of vaccine hesitancy in Africa?. Public health. (Not OA)
 
Afolabi, A.A. and Ilesanmi, O.S., 2021. Dealing with vaccine hesitancy in Africa: the prospective COVID-19 vaccine context. The Pan African Medical Journal, 38.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825371/

 

EbscoHost

Ogunleye, O.O., Godman, B., Fadare, J.O., Mudenda, S., Adeoti, A.O., Yinka-Ogunleye, A.F., Ogundele, S.O., Oyawole, M.R., Schönfeldt, M., Rashed, W.M. and Galal, A.M., 2022. Coronavirus disease 2019 (COVID-19) pandemic across Africa: current status of vaccinations and implications for the future. Vaccines, 10(9), p.1553.
https://www.mdpi.com/2076-393X/10/9/1553
 
Mohamed, R., White, T.M., Lazarus, J.V., Salem, A., Kaki, R., Marrakchi, W., Kheir, S.G., Amer, I., Ahmed, F.M., Khayat, M.A. and Al-Abdullah, N., 2022. COVID-19 vaccine acceptance and associated factors among people living with HIV in the Middle East and North Africa region. Southern African Journal of HIV Medicine, 23(1), p.9.
https://sajhivmed.org.za/index.php/hivmed/article/view/1391
 
Nachega, J.B., Sam-Agudu, N.A., Siedner, M.J., Rosenthal, P.J., Mellors, J.W., Zumla, A., Hermans, M.P., Ntakwinja, M.B., Mukwege, D.M., Langenegger, E. and Mofenson, L.M., 2022. Prioritizing Pregnant Women for Coronavirus Disease 2019 Vaccination in African Countries. Clinical Infectious Diseases. (Not OA)
 
Abstract: Coronavirus disease 2019 (COVID-19) in pregnancy is associated with excess maternal and infant morbidity and mortality in both African and higher-resource settings. Furthermore, mounting evidence demonstrates the safety and efficacy of COVID-19 vaccination for pregnant women and infants. However, national guidelines in many African countries are equivocal or lack recommendations on COVID-19 vaccine in pregnancy. We summarize key data on COVID-19 epidemiology and vaccination among pregnant African women to highlight major barriers to vaccination and recommend 4 interventions. First, policymakers should prioritize pregnant women for COVID-19 vaccination, with a target of 100% coverage. Second, empirically supported public health campaigns should be sustainably implemented to inform and support pregnant women and their healthcare providers in overcoming vaccine hesitancy. Third, COVID-19 vaccination for pregnant women should be expanded to include antenatal care, obstetrics/gynecology, and targeted mass vaccination campaigns. Fourth, national monitoring and evaluation of COVID-19 vaccine uptake, safety, surveillance, and prospective outcomes assessment should be conducted.
 
 
 

 

 

 

 
 
 

Google Scholar

Lazarus, J.V., Wyka, K., White, T.M., Picchio, C.A., Gostin, L.O., Larson, H.J., Rabin, K., Ratzan, S.C., Kamarulzaman, A. and El-Mohandes, A., 2023. A survey of COVID-19 vaccine acceptance across 23 countries in 2022. Nature Medicine, pp.1-10.

https://www.nature.com/articles/s41591-022-02185-4

Kagina, B. 2022. Making COVID vaccines in Africa: advances and sustainability issues. The Conversation

https://theconversation.com/making-covid-vaccines-in-africa-advances-and-sustainability-issues-182683

Kwon, R. and Rahmati, M., 2022. Global, regional, and national COVID-19 vaccination rate in 237 countries and territories, March 2022: a systematic analysis for World Health Organization COVID-19 Dashboard, Release 2. Life Cycle, 2.
DOI: https://doi.org/10.54724/lc.2022.e15
 
Stewart, R., Madonsela, A., Tshabalala, N., Etale, L. and Theunissen, N., 2022. The importance of social media users’ responses in tackling digital COVID-19 misinformation in Africa. Digital Health, 8, p.20552076221085070.
https://journals.sagepub.com/doi/full/10.1177/20552076221085070
 
The Immunization Action Coalition https://www.immunize.org/covid-19/
 

SA Corana Virus Academic Articles (Ministerial Advisory Committee) MAC  https://sacoronavirus.co.za/category/academic-articles/

Combrink, H MvE, Smart, B T H, Hazelhurst, S, Marivate, V. 2022. COVID lessons: scientists without quality data are like unarmed soldiers in a war zone. The Conversation.

https://theconversation.com/covid-lessons-scientists-without-quality-data-are-like-unarmed-soldiers-in-a-war-zone-175102

Panero, M.S., Khuri-Bulos, N., Biscayart, C., Bonvehí, P., Hayajneh, W. and Madhi, S.A., 2020. The role of National Immunization Technical Advisory Groups (NITAG) in strengthening health system governance: Lessons from three middle-income countries—Argentina, Jordan, and South Africa (2017–2018). Vaccine, 38(45), pp.7118-7128. (Not OA)

 

Web of Science

Scopus

Cochrane

Struyf, T., Deeks, J.J., Dinnes, J., Takwoingi, Y., Davenport, C., Leeflang, M.M., Spijker, R., Hooft, L., Emperador, D., Domen, J. and Horn, S.R., 2021. Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID‐19. Cochrane Database of Systematic Reviews, (2). (Not OA)
 
Houghton, C., Meskell, P., Delaney, H., Smalle, M., Glenton, C., Booth, A., Chan, X.H.S., Devane, D. and Biesty, L.M., 2020. Barriers and facilitators to healthcare workers’ adherence with infection prevention and control (IPC) guidelines for respiratory infectious diseases: a rapid qualitative evidence synthesis. Cochrane Database of Systematic Reviews, (4). (Not OA)